FREE Case Review (866) 588-0600

Nexium Interstitial Nephritis Lawsuit Attorney

Side effects of the heartburn medication Nexium may include interstitial nephritis, a kidney disorder that occurs when the spaces between the kidney tubules become swollen and inflamed.
Award Logos
Awards & recognition
C.L. Mike Schmidt Published by C.L. Mike Schmidt

Side effects of the heartburn medication Nexium (generic: esomeprazole) may include interstitial nephritis, a kidney disorder that occurs when the spaces between the kidney tubules become swollen and inflamed.

Free Confidential Lawsuit Evaluation: If you or a loved one was injured, you should contact our law firm immediately. You may be entitled to compensation by filing a suit against the manufacturer and our lawyers can help.

Update: Nexium Lawsuit Filed in New York

September 21, 2016 – A man who claims he developed chronic kidney disease (CKD) as a result of taking Nexium has filed a products liability lawsuit (case #16-04801) against AstraZeneca in the U.S. District Court for the Eastern District of New York. Plaintiff alleges that the manufacturer was aware of the link between Nexium and kidney disease, yet failed to adequately about this risk.

What’s the Problem?

According to research published in the journal BMC Nephrology in July 2013 [1], previous studies [2] and numerous biopsy-confirmed case reports have strongly suggested an association between the use of notorious proton pump inhibitor (PPI) drugs like Nexium and acute interstitial nephritis, or AIN. The New England Journal of Medicine (NEJM) [3] 2006 released information about a case series and literature review that found a link between proton pump inhibitors and the development of AIN. Although many of these patients experienced some degree of recovery of renal function, others suffered permanent kidney damage as a result of PPI use.

Related Article: Nexium Lawsuit Update

FDA Warning

In December 2014, the U.S. Food & Drug Administration (FDA) announced new warnings [4] would be added to the labeling of proton pump inhibitors regarding an increased risk for acute interstitial nephritis.

Acute interstitial nephritis has been observed in patients taking PPIs including Nexium,”  FDA said. “Acute interstitial nephritis may occur at any point during PPI therapy and is generally attributed to an idiopathic hypersensitivity reaction. Discontinue Nexium if acute interstitial nephritis develops.”

What is Interstitial Nephritis?

Interstitial nephritis is a kidney disorder that occurs when there is excessive swelling between the kidney tubules. The kidneys filter blood and wastes from the body; kidney tubules reabsorb water and organic compounds, removing substances the body doesn’t need through the urine. Swelling of these tubules can cause a number of kidney symptoms ranging from mild to severe. Interstitial nephritis can be temporary (acute), or it may be long-lasting (chronic) and get worse over time.


Signs and symptoms of interstitial nephritis may include:

  • Blood in the urine
  • Fever
  • Increased or decreased urine output
  • Mental status changes (drowsiness, confusion, coma)
  • Nausea, vomiting
  • Rash
  • Swelling of the body (any area)
  • Weight gain (from retaining fluid)


Treatment for interstitial nephritis depends on what’s causing the problem. If Nexium is determined to be the likely cause, your doctor may recommend switching to a heartburn drug with fewer potential side effects. However, you should never switch or quit taking a medication without talking to your doctor first.

Other things you can do to help treat interstitial nephritis include:

  • Limiting salt and fluid in the diet can improve swelling and high blood pressure (hypertension).
  • Limiting protein intake can help control the buildup of wastes in the blood (azotemia) which can lead to symptoms of acute kidney failure.
  • Corticosteroids or stronger anti-inflammatory drugs can sometimes be helpful in treating the condition.

Related Articles:

See all related dangerous drug lawsuits we’ve taken on.

Choose our lawyers

Have you or a loved one suffered from the adverse side effects caused by defective medication?

Do I have a Nexium Interstitial Nephritis Lawsuit?

The Pharmaceutical Litigation Group at Schmidt & Clark, LLP law firm is an experienced team of trial lawyers that focus on the representation of plaintiffs in Nexium lawsuits. We are handling individual litigation nationwide and currently accepting new nephritis cases in all 50 states.

Free Confidential Case Evaluation: Again, if you or a loved one was injured by Nexium side effects, you should contact our law firm immediately. You may be entitled to a settlement by filing a suit and we can help.

Free Confidential Case Evaluation

Verified 100% Secure SiteTo contact us for a free review of your potential case, please fill out the form below or call us toll free 24 hrs/day by dialing: (866) 588-0600.