Nexium Lawsuit | 2025 Latest Updates

Nexium Lawsuit Overview

Nexium lawsuits center on allegations that AstraZeneca failed to adequately warn consumers about serious health risks associated with their popular heartburn medication.

Thousands of patients have reported severe kidney injuries, including chronic kidney disease and kidney failure, after taking Nexium.

The litigation also involves claims related to increased risks of bone fractures, stomach cancer, and other serious side effects that plaintiffs say were downplayed or concealed by the manufacturer.

Latest Nexium Lawsuit Updates

• October 2023– AstraZeneca agreed to pay $425 million to resolve lawsuits linking proton pump inhibitors (including Nexium) to kidney injuries, affecting thousands of plaintiffs nationwide.
• March 2021 – A Louisiana judge denied AstraZeneca’s motion to dismiss a defect and warning claims lawsuit filed by a woman who developed kidney failure after taking Nexium.
• 2016 – AstraZeneca paid a $7.9 million penalty to the U.S. Department of Justice for engaging in a kickback scheme involving the sale of Nexium and Prilosec.

Related Article: Prilosec Lawsuit Update

FDA Reports and Statistics

Scientific studies have highlighted significant risks associated with Nexium and other PPIs:

Kidney-Related Risks

• JAMA Internal Medicine linked long-term PPI use to a 45% increased risk of chronic kidney disease (CKD) [1].
• The Atherosclerosis Risk in Communities (ARIC) Study found over-the-counter PPI users had a 45% increased risk of developing CKD compared to non-users [2].
• Journal of the American Society of Nephrology found a 28% increased risk of CKD for PPI users compared to H2 blockers like Zantac [3].

Cardiovascular Risks

• PLOS ONE associated PPIs with increased risks of heart failure and death in coronary artery disease patients [4].
• International Journal of Cardiology found Nexium users were 6 times more likely to suffer from anemia and a worsening metabolic profile [5].

Muscle-Related Risks

• Medicine reported that a single intravenous dose of Nexium caused a man to develop rhabdomyolysis, a severe muscle condition [6].

The FDA has issued several safety communications regarding Nexium and other proton pump inhibitors. In December 2014, the FDA announced that new warnings would be added to PPI labeling regarding an increased risk for acute interstitial nephritis [7].

In May 2010, the FDA issued a warning highlighting the risks associated with prolonged Nexium use and bone fractures, mandating enhanced warning labels on Nexium and other PPIs.

The warning specifically identified hip, wrist, and spine fractures as associated with prolonged PPI use, with the greatest risk observed in patients using high doses for a year or more.

“Acute interstitial nephritis has been observed in patients taking PPIs including Nexium and Prilosec. Acute interstitial nephritis may occur at any point during PPI therapy and is generally attributed to idiopathic hypersensitivity reaction. Discontinue Nexium if acute interstitial nephritis develops.”- U.S. Food and Drug Administration.

Nexium Risk Statistics

• 45% increased risk of Chronic Kidney Disease (CKD).
• 8x higher stomach cancer risk after 3 years.
• 16-21% increased heart attack risk.
• 31% higher risk of hepatic encephalopathy.
• $87.2B annual CKD treatment costs in the U.S.

“Our finding that the lining of blood vessels is impaired by proton pump inhibitors is a unifying mechanism for the reports that PPI users are at increased risk for heart attack, stroke and renal failure. They {PPIs} are being used ubiquitously, for long periods of time. They aren’t being used as originally approved.”- John Cooke, Houston Methodist Research Institute Chair of Cardiovascular Sciences .

Related Article: Zantac Lawsuit Update

Nexium Injuries & Side Effects

Proton pump inhibitors (PPIs) like Nexium have been linked to a range of serious side effects, from immediate risks to long-term complications.

• Kidney-Related Injuries: Chronic kidney disease (45% increased risk), acute interstitial nephritis, kidney failure requiring dialysis or transplant.
• Cardiovascular Issues: 16-21% increased heart attack risk [8], premature aging of blood vessels [9].
• Bone Fractures: Increased risk of hip, wrist, and spine fractures due to decreased bone density.
• Cancer Risks: 8x higher stomach cancer risk after 3+ years of use [10].
• Gastrointestinal Problems: Clostridium difficile infections, Campylobacter infections.
• Respiratory Issues: 89% increased pneumonia risk, especially in vulnerable populations.

Other less severe side effects include headache, diarrhea, nausea , decreased appetite, constipation, dry mouth, abdominal pain, chest pain, dark urine, fast heartbeat, and fever.

New Studies Link PPI Side Effects to Increased Dementia Risk

Proton pump inhibitors have recently come under scrutiny following studies suggesting a potential link between long-term use and an increased risk of dementia.

In recent years, researchers have examined whether extended use of PPIs may have unintended consequences on cognitive health—particularly in older adults.

A notable study published in Neurology (2023) followed over 5,700 individuals aged 45 and older over a period of nearly 10 years.

The study found that participants who used PPIs for more than four years had a 33% higher risk of developing dementia compared to those who had never used the drugs or had used them for a shorter duration [11.].

While the findings don’t definitively prove causation, they do raise significant concerns about prolonged use, especially in aging populations already at elevated risk for cognitive decline. Several mechanisms have been proposed to explain the observed association.

One theory is that PPIs can reduce the absorption of vitamin B12, a nutrient essential for brain function, and chronic deficiency of which has been linked to neurological problems, including memory loss and cognitive impairment.

Another theory suggests that PPIs may alter the gut microbiome, leading to inflammation and reduced cognitive resilience.

Additionally, chronic suppression of stomach acid may indirectly affect protein processing or amyloid plaque clearance, both of which play a role in the development of Alzheimer’s disease.

Other research has explored the relationship between PPI-induced magnesium deficiency and neurological function, as magnesium is known to support synaptic plasticity and brain health.

Despite these concerns, it’s important to note that not all studies have found a strong or consistent association.

Some have questioned whether the correlation might be due to confounding factors, such as the underlying conditions for which PPIs are prescribed.

For instance, chronic illness, poor diet, or other medications may play a more direct role in dementia development than PPIs themselves.

Nevertheless, health experts and organizations are urging caution. The current medical consensus advises that PPIs should be used at the lowest effective dose for the shortest duration necessary.

Long-term use should be reassessed regularly, especially in older adults, to weigh the benefits against potential risks.

If you’re taking a PPI and are concerned about cognitive health, you should consult your healthcare provider before stopping or changing your medication.

In some cases, lifestyle changes such as dietary modifications, weight loss, and avoiding late-night eating may reduce the need for long-term acid suppression therapy.

Do You Qualify for a Nexium Lawsuit?

You may qualify for a Nexium lawsuit if:

• You used Nexium or another PPI medication regularly.
• You were diagnosed with chronic kidney disease, acute interstitial nephritis, kidney failure, or other serious side effects.
• Your injuries required medical treatment or hospitalization.
• You can provide medical documentation linking your injuries to Nexium use.

Evidence Required for a Nexium Lawsuit

To strengthen your case, you’ll need to gather:

• Medical records documenting your Nexium use
• Diagnosis confirmation from healthcare providers
• Records of treatments received for your injuries
• Evidence of proper usage according to prescription or instructions

Damages You Can Recover

Successful Nexium kidney disease lawsuits may provide compensation for:

• Medical expenses, including past and future treatments
• Lost wages and diminished earning capacity
• Pain and suffering
• Punitive damages in cases of manufacturer negligence

Related Article: Prilosec Lawsuit Update

Nexium Recall Information

While there has been no comprehensive recall of Nexium, the FDA has required updated warning labels to reflect the serious risks associated with the medication.

These include warnings about bone fracture risks, acute interstitial nephritis, and other potential complications. Patients currently taking Nexium should consult with their healthcare providers about these risks.

The warning on the FDA website states:

“Be aware that an increased risk of fractures of the hip, wrist, and spine has been reported in some studies of patients using proton pump inhibitors. The greatest increased risk for these fractures was seen in patients who receive high doses of these medications or use them longer (a year or more).”

Has a Nexium Class Action Lawsuit Been Filed?

A consumer fraud Nexium class action lawsuit was filed against AstraZeneca, alleging deceptive marketing practices with Nexium.

In the lawsuit entitled Commonwealth Care Alliance v. AstraZeneca Pharmaceuticals L.P., Docket No. 05-0269, plaintiffs allege the drugmaker violated a Massachusetts state law by deceptively marketing Nexium as superior to Prilosec (generic: omeprazole).

The lawsuit asked the federal court to order AstraZeneca to pay restitution to purchasers for amounts they allegedly overpaid, award money damages for medical expenses, or grant other relief.

Statute of Limitations for Nexium Lawsuits

The statute of limitations for filing a Nexium lawsuit varies by state but typically ranges from 1-6 years from the date of injury or diagnosis.

In some jurisdictions, the “discovery rule” may extend this timeline if you could not reasonably have known about the connection between Nexium and your injuries until later.

It’s crucial to consult with a Nexium attorney promptly to ensure you don’t lose your right to seek compensation.

Related Articles:

• Prilosec Side Effects Lawsuit
• Prevacid (Lansoprazole) Litigation
• Dexilant Kidney Failure Suit

FAQs

1. Why Are Lawsuits Being Filed Against Nexium?

Lawsuits are being filed against Nexium because users claim the drug caused serious kidney-related injuries. These include chronic kidney disease, acute kidney injury, and even kidney failure. Plaintiffs argue that AstraZeneca, the manufacturer, failed to adequately warn the public about these risks despite evidence linking long-term Nexium use to kidney problems.

2. How Can a Nexium Attorney Help?

A Nexium attorney can help by reviewing your medical records, determining if you have a valid claim, and filing a lawsuit on your behalf. They handle all communication with the pharmaceutical company and seek compensation for medical bills, lost income, and pain and suffering. An experienced lawyer can also guide you through the legal process and help build a strong case.

3. What Is the Current Status of Nexium Litigation?

As of now, Nexium lawsuits have been consolidated into multidistrict litigation (MDL) along with other proton pump inhibitor (PPI) drugs. While no global settlement has been reached yet, some cases have moved into bellwether trials to help determine potential outcomes. The litigation is ongoing, and new claims are still being accepted.

See all related dangerous drug lawsuits we’ve taken on.

Get Your Free Nexium Lawsuit Evaluation With Our Lawyers

Time is limited to pursue legal action for Nexium-related injuries. Many states have statutes of limitations as short as one year from the date of injury or discovery of your condition. Don’t risk losing your right to compensation.

Our experienced Nexium attorneys offer:

• Free, confidential case evaluations
• No upfront costs or fees
• Payment only if we win your case

If you or a loved one has suffered kidney damage, bone fractures, or other serious complications after taking Nexium, contact Schmidt & Clark, LLP today. Our dedicated team will fight for the compensation you deserve.

References:

1. http://archinte.jamanetwork.com/article.aspx?articleid=2481157
2. https://www.nhlbi.nih.gov/science/population-and-epidemiology-studies
3. http://journals.lww.com/jasn/pages/default.aspx
4. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0169826
5. https://www.internationaljournalofcardiology.com/article/S0167-5273(16)31065-8/abstract
6. http://journals.lww.com/md-journal/Fulltext/2016/07190/Rhabdomyolysis_associated_with_single_dose.50.aspx
7. https://www.fda.gov/Safety/MedWatch/SafetyInformation/ucm290945.htm
8. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0124653
9. https://circres.ahajournals.org/content/118/12/e36
10. http://gut.bmj.com/content/early/2017/09/18/gutjnl-2017-314605