Xeljanz Causing Blood Clots in the Lungs
What You Need to Know

Study Suggests Increased Blood Clot Risk with Xeljanz

An ongoing post-marketing study of Xeljanz and Xeljanz XR identified a statistically significant rate of pulmonary embolism for rheumatoid arthritis (RA) patients using the 10 mg twice daily dose of Xeljanz compared to a control group given tumor necrosis factor inhibitors (TNFis), a different group of RA drug.

The study also found an increased risk of death compared to participants taking the 5 mg twice daily dose and in the control group. FDA required this safety study to be performed when it originally approved Xeljanz in 2012.

After finding the increased risk of pulmonary embolism in subjects taking the higher dose of Xeljanz, the study’s Data Safety Monitoring Board (DSMB) required those patients to be treated with the lower dose.

In Feb. 2019, FDA released a safety announcement about the increased risk of pulmonary embolism and death in RA patients taking the 10 mg twice daily dose of Xeljanz or Xeljanz XR. The agency stated it is “working with the manufacturer to evaluate other currently available safety information for tofacitinib and will update the public with any new information based on…ongoing review.”

Related Article: Xeljanz Lawsuit Update

Pulmonary Embolism Symptoms

Symptoms of a blood clot in the lung can vary greatly from patient to patient, depending on how much of the lung is involved, the size of the clot, and whether the patient has an underlying disease or health condition.

Common symptoms of a pulmonary embolism include:

• Shortness of breath
• Chest pain
• Fainting

Other symptoms that can occur in patients with a blood clot in the lung include:

1. A cough that may include bloody or blood-streaked mucus
2. Rapid or irregular heartbeat
3. Lightheadedness or dizziness
4. Excessive sweating
5. Fever
6. Leg pain or swelling, or both, usually in the back of the lower leg
7. Clammy or discolored skin (cyanosis)

Treatment

Pulmonary embolism is usually treated in a hospital setting, where the condition can be monitored closely. The length of treatment and hospital stay will vary depending on the severity of the clot. The main treatment for a pulmonary embolism is an anticoagulant (blood thinner) drug.

Depending on the severity of the clot and its effect on the other organs, the patient may also be required to undergo thrombolytic therapy, surgery, or interventional procedures to improve blood flow in their pulmonary arteries.

FAQs

How does Xeljanz increase the risk of pulmonary embolism?

The exact mechanism is not fully understood, but Xeljanz has been shown to increase the tendency for blood clot formation, leading to a higher risk of pulmonary embolism, particularly at higher doses or in patients with pre-existing risk factors.

Who is at greater risk of developing blood clots from Xeljanz?

Patients with a history of blood clots, cardiovascular disease, or those taking higher doses of Xeljanz may have an increased risk. It is important to discuss individual risk factors with your healthcare provider.

What should I do if I suspect I have a pulmonary embolism while taking Xeljanz?

Seek emergency medical attention immediately if you suspect you have a pulmonary embolism. Early treatment is crucial to prevent serious complications or death.

Are there alternatives to Xeljanz that do not carry the same risk?

There are alternative medications for rheumatoid arthritis and other conditions treated by Xeljanz. Your healthcare provider can help determine the best treatment option based on your specific medical history and risk factors.

Related Articles:

• Xeljanz XR Lawsuit
• Xeljanz Dosage and Administration
• Xeljanz and Alcohol – A Toxic Combination?

See all related dangerous drug lawsuits our attorneys covered so far.

Get a Free Lawsuit Evaluation With Our Attorneys

The Pharmaceutical Litigation Group at Schmidt & Clark, LLP law firm is an experienced team of trial attorneys that focus on the representation of plaintiffs in Lawsuits. We are handling individual litigation nationwide and currently accepting new class action lawsuits against Xeljanz in all 50 states.

Free Lawsuit Evaluation: Again, if you were harmed after taking Xeljanz to treat rheumatoid arthritis, you should contact our attorneys immediately. Xeljanz patients may be entitled to a settlement for medical expenses by filing a class action lawsuit and our Attorneys can help.