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Nexium Interstitial Nephritis Lawsuit

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Side effects of the heartburn medication Nexium (generic: esomeprazole) may include interstitial nephritis, a kidney disorder that occurs when the spaces between the kidney tubules become swollen and inflamed.

Free Confidential Lawsuit Evaluation: If you or a loved one was injured, you should contact our law firm immediately. You may be entitled to compensation by filing a suit against the manufacturer and our lawyers can help.

What’s the Problem?

According to research published in the journal BMC Nephrology in July 2013, previous studies and numerous biopsy-confirmed case reports have suggested an association between the use of proton pump inhibitor (PPI) drugs like Nexium and acute interstitial nephritis, or AIN. The New England Journal of Medicine (NEJM) in 2006 released information about a case series and literature review that found a link between proton pump inhibitors and the development of AIN. Although many of these patients experienced some degree of recovery of renal function, others suffered permanent kidney damage as a result of PPI use.

FDA Warning

In December 2014, the U.S. Food & Drug Administration (FDA) announced new warnings would be added to the labeling of proton pump inhibitors regarding an increased risk for acute interstitial nephritis.

Acute interstitial nephritis has been observed in patients taking PPIs including Nexium,”  FDA said. “Acute interstitial nephritis may occur at any point during PPI therapy and is generally attributed to idiopathic hypersensitivity reaction. Discontinue Nexium if acute interstitial nephritis develops.”

What is Interstitial Nephritis?

Interstitial nephritis is a kidney disorder that occurs when there is excessive swelling between the kidney tubules. The kidneys filter blood and wastes from the body; kidney tubules reabsorb water and organic compounds, removing substances the body doesn’t need through the urine. Swelling of these tubules can cause a number of kidney symptoms ranging from mild to severe. Interstitial nephritis can be temporary (acute), or it may be long-lasting (chronic) and get worse over time.

Symptoms

Signs and symptoms of interstitial nephritis may include:

  • Blood in the urine
  • Fever
  • Increased or decreased urine output
  • Mental status changes (drowsiness, confusion, coma)
  • Nausea, vomiting
  • Rash
  • Swelling of the bod (any area)
  • Weight gain (from retaining fluid)

Treatment

Treatment for interstitial nephritis depends on what’s causing the problem. If Nexium is determined to be the likely cause, your doctor may recommend switching to a heartburn drug with fewer potential side effects. However, you should never switch or quit taking a medication without talking to your doctor first.

Other things you can do to help treat interstitial nephritis include:
Limiting salt and fluid in the diet can improve swelling and high blood pressure (hypertension).
Limiting protein intake can help control the buildup of wastes in the blood (azotemia) which can lead to symptoms of acute kidney failure.
Corticosteroids or stronger anti-inflammatory drugs can sometimes be helpful in treating the condition.

Do I have a Nexium Interstitial Nephritis Lawsuit?

The Pharmaceutical Litigation Group at our law firm is an experienced team of trial lawyers that focus on the representation of plaintiffs in Nexium lawsuits. We are handling individual litigation nationwide and currently accepting new nephritis cases in all 50 states.

Free Confidential Case Evaluation: Again, if you or a loved one was injured by Nexium side effects, you should contact our law firm immediately. You may be entitled to a settlement by filing a suit and we can help.

Nexium Lawsuit Filed in Illinois

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A man from Madison County, Illinois, who allegedly developed kidney failure after taking the proton pump inhibitor drug Nexium (generic: esomeprazole) has filed a class action lawsuit against AstraZeneca.

Free Confidential Lawsuit Evaluation: If you or a loved one has been injured by Nexium side effects, you should contact our law firm immediately. You may be entitled to compensation by filing a suit against the manufacturer and our lawyers can help.

What’s the Problem?

May 9, 2016 – According to the lawsuit (PDF), Plaintiff Harry Mason began taking Nexium in 2006, which ultimately led to his development of kidney failure requiring the need for a kidney transplant. The complaint states that AstraZeneca committed fraud by failing to adequately warn consumers of Nexium side effects. Mason is alleging charges of common law fraud, fraudulent misrepresentation, as well as negligent and intentional infliction of emotional distress against the drugmaker.

“[AstraZeneca has] had notice of serious adverse health outcomes through case reports, clinical studies and post-market surveillance,” the lawsuit states. “Specifically, Defendants had received numerous case reports of kidney injuries in patients that had ingested Nexium by as early as 2004. These reports of numerous kidney injuries put Defendants on notice as to the excessive risks of kidney injuries related to the use of Nexium.”

Mason’s claim is believed to be one of the first in what will likely be a steady stream of litigation alleging side effects from Nexium and other proton pump inhibitors (PPIs). Plaintiffs in these cases allege that if warnings had been provided about the risk of acute interstitial nephritis, chronic kidney disease (CKD) and kidney failure, many individuals may have been able to avoid these severe and potentially life-threatening injuries. In addition to Nexium, other PPIs include Prilosec (omeprazole), Protonix (pantoprazole), Prevacid (lansoprazole), Dexilant (dexlansoprazole), Aciphex (rabeprazole) and their generic equivalents.

Mason is seeking a jury trial, punitive and compensatory damages, and litigation costs. The complaint was filed May 3 in the U.S. District Court for the Southern District of Illinois under case number 3:16-cv-00493.

Do I Have a Nexium Lawsuit?

The Pharmaceutical Litigation Group at our law firm is an experienced team of trial lawyers that focus on the representation of plaintiffs in Nexium lawsuits. We are handling individual litigation nationwide and currently accepting new injury and death cases in all 50 states.

Free Confidential Case Evaluation: Again, if you’ve been injured by Nexium, you should contact our law firm immediately. You may be entitled to a settlement by filing a suit and we can help.

Nexium Kidney Failure Lawsuit

Nexium 20mg

The heartburn medication Nexium (esomeprazole magnesium) has been linked to an increased risk for nephritis (inflammation of the kidneys) and chronic kidney disease (CKD), conditions that can lead to kidney failure if left untreated.

Free Confidential Lawsuit Evaluation: If you suffered kidney failure or other damage to your kidneys after taking Nexium, you should contact our law firm immediately. You may be entitled to compensation by filing a suit against the manufacturer and our lawyers can help.

Update: Indiana Man Alleges Kidney Failure from Nexium

May 9, 2016 – A man from Madison County, Illinois, who allegedly developed kidney failure after using Nexium has filed a class action lawsuit (PDF) against AstraZeneca. According to the lawsuit, plaintiff Harry Mason began taking Nexium in 2006, which ultimately led to his development of kidney failure requiring the need for a kidney transplant. The complaint is believed to be one of the first in what will likely be a steady stream of litigation alleging side effects from Nexium and other PPIs.

What is Nexium?

Since it was approved by the U.S. Food & Drug Administration (FDA) in September 2001, Nexium has become one of the most widely prescribed drugs in America, and generated about $6 billion in annual sales for AstraZeneca before it lost patent protection and became available as a generic.

Nexium is used to treat the symptoms of gastroesophageal reflux disease (GERD), heartburn, stomach ulcers and inflammation of the esophagus. It belongs to a class of drugs called proton pump inhibitors (PPI) which includes Prilosec (omeprazole), Prevacid (lansoprazole), Protonix (pantoprazole) and others.
AstraZeneca has aggressively marketed the “Purple Pill” as safe and effective; however, recent studies have found that users of the drug may face an increased risk of long-term kidney damage and even full-blown kidney failure.

PPIs Linked to Nephritis: FDA Warning

In December 2014, FDA announced new warnings to the labeling of Nexium and other PPI heartburn medications regarding a form of kidney damage called acute interstitial nephritis, which is characterized by a sudden inflammation of the kidneys that can lead to more severe problems.

Acute interstitial nephritis has been observed in patients taking PPIs including Nexium,” the warning states. “Acute interstitial nephritis may occur at any point during PPI therapy and is generally attributed to idiopathic hypersensitivity reaction. Discontinue Nexium if acute interstitial nephritis develops.”

Nexium Kidney Damage Studies

In April 2015, a study published in the medical journal CMAJ Open found that PPI users had a 2.5-fold increased risk of developing acute kidney injury, as well as a 3 times higher risk of acute interstitial nephritis compared to patients who did not take the drugs. The study’s authors highlighted the importance of doctors understanding the risk of these injuries, indicating that patients should be monitored and indiscriminate PPI use should be discouraged.

Another study published in JAMA Internal Medicine in January 2016 found that PPIs may significantly increase the risk of chronic kidney disease (CKD). The researchers looked at data on more than 10,000 participants in the the Atherosclerosis Risk in Communities Study (ARIC), and determined that PPI users had a 45% increased risk of CKD compared to non-users. When the figures were adjusted for demographics, socioeconomic and clinical variables, a 50% increased risk was detected. If left untreated, kidney disease and nephritis may lead to kidney failure (end-stage renal disease or ESRD), the need for life-long dialysis treatment or a kidney transplant.

Kidney Failure Symptoms

According to the American Kidney Fund, kidney failure is the last stage of CKD. When the kidneys fail, it means they have stopped functioning adequately enough for the patient to survive without dialysis or a kidney transplant. Signs and symptoms of kidney failure include:

  • Itching
  • Muscle cramps
  • Nausea / vomiting
  • Not feeling hungry
  • Swelling in the feet and/or ankles
  • Changes in urinary output
  • Breathlessness
  • Trouble sleeping

Treatment

Patients with ERSD will require dialysis or a kidney transplant to survive. There is no cure for kidney failure, but many people with the condition live long lives while undergoing dialysis or after having a kidney transplant. There are many options available to treat kidney failure, including kidney transplant and several types of dialysis. Your doctor can help you figure out which treatment option is best for you.

Proton Pump Inhibitors Linked to Kidney Disease, Study Finds

April 14, 2016 – Taking Nexium or other PPI heartburn medication may increase your risk of chronic kidney disease and renal failure, according to a study published today in the Journal of the American Society of Nephrology (JASN). The researchers found that those who take proton pump inhibitors are more likely than people who take histamine H2 receptor blockers (Pepcid, Tagamet, Zantac) to develop CKD or end-stage renal disease (ESRD) over a 5-year period.

Do I Have a Nexium Kidney Failure Lawsuit?

The Pharmaceutical Litigation Group at our law firm is an experienced team of trial lawyers that focus on the representation of plaintiffs in Nexium lawsuits. We are handling individual litigation nationwide and currently accepting new kidney failure cases in all 50 states.

Free Confidential Case Evaluation: Again, if you or a loved one developed kidney failure from Nexium, you should contact our law firm immediately. You may be entitled to a settlement by filing a suit and we can help.

Nexium Bone Fracture Lawsuit

Nexium 20mg

AstraZeneca’s widely-prescribed heartburn medication Nexium (esomeprazole magnesium) has recently been linked to bone fractures and bone breaks, particularly among users who have taken the drug for a long period of time. In May 2010, the U.S. Food & Drug Administration (FDA) required that labels of Nexium and other proton pump inhibitors (PPIs) be updated to include information about this risk. Recent studies have also linked PPI heartburn medications to chronic kidney disease (CKD), renal failure and nephritis (inflammation of the kidneys).

Free Confidential Lawsuit Evaluation: If you or a loved one suffered kidney damage after taking Nexium, you should contact our law firm immediately. You may be entitled to compensation by filing a suit against the manufacturer and our lawyers can help.

Overview

First approved by the FDA in February 2001, Nexium is a proton pump inhibitor drug used to treat the symptoms of gastroesophageal reflux disease (GERD) and other conditions involving excessive stomach acid. It is AstraZeneca’s best-selling drug, as well as the third best-selling medication in the world, generating over $5.2 billion in sales in 2008 alone. Esomeprazole, the active ingredient in Nexium, is now manufactured by several companies under the brand names:

Nexium Bone Fractures

It has been theorized that Nexium has the potential to cause bone fractures because it reduces acid in the stomach, which in turn lowers the amount of calcium dissolved and absorbed into the body. Nexium also interferes with the body’s ability to break down and rebuild bone by manipulating the acid production of osteoclasts. Additionally, the reduction of B-12 by raising homocysteine may make the bones more fragile and prone to fractures or breaks.

“Epidemiology studies suggest a possible increased risk of bone fractures with the use of proton pump inhibitors for one year or longer, or at high doses,” said Dr. Joyce Korvick, FDA’s Division of Gastroenterology Products deputy director for safety. “Because these products are used by a great number of people, it’s important for the public to be aware of this possible increased risk and, when prescribing proton pump inhibitors, health care professionals should consider whether a lower dose or shorter duration of therapy would adequately treat the patient’s condition.”

FDA Warning on Nexium

The FDA’s review of several long-term studies which found an increased risk of hip, wrist, and spine fractures in PPIs users prompted the administration in May 2010 to revise labeling requirements for the drugs. The research indicated that these fractures occurred more often in patients who used PPIs like Nexium for more than one year at a higher dose. Then in 2011, researchers reiterated the fact that the risk of bone fractures greatly increased when using PPIs. Scientists found that PPI users who smoked had a 51% increased risk of suffering a hip fracture, and concluded that the longer the duration of use, the greater the risk of a fracture.

Nexium Bone Fracture Lawsuit Filed in Texas

In April 2011, a lawsuit was filed on behalf of an Ohio woman who suffered severe bone deterioration and broken bones after taking Nexium. Filed in the U.S. District Court in Houston, the complaint alleges that 58-year-old Ginny Begin suffered serious bone deterioration after taking Nexium on a daily basis from 2003 until early 2011. According to the lawsuit, “[A]s early as 2006, studies found PPI’s, by reducing hydrochloric acid in the stomach, interfere with the body’s ability to absorb calcium, thus speeding up bone loss and leading to an increased number of fractures. In total, six studies have found the risk of fracture significantly increased for those patients over 50 years of age who took a prescription-strength PPI, like Nexium, or who took any PPI regularly for more than one year. Specifically, use of PPI’s increases the risk of fractures in women up to 34 percent.”

PPI Heartburn Medications May Increase Risk of Kidney Disease, Study Finds

In addition to increasing the risk of bone fractures and breaks, Nexium and other PPIs may cause chronic kidney disease (CKD) and other kidney damage in some users. According to a Jan. 2016 study published in JAMA Internal Medicine, PPI users had a 45% increased risk of developing CKD compared to non-users.

“I think it’s a pretty big concern,” says Adam Schoenfeld, an internal medicine resident at the University of California, San Francisco, who co-authored an editorial accompanying the study. “When they first came out they weren’t associated with side effects, or we didn’t think they were. So we put [people] on this medication thinking: ‘It’s a quick fix and they’re very safe.’ But in actuality they’re associated with a range of side effects.”

Do I have a Nexium Lawsuit?

The Pharmaceutical Litigation Group at our law firm is an experienced team of trial lawyers that focus on the representation of plaintiffs in Nexium lawsuits. We are handling individual litigation nationwide and currently accepting new kidney damage cases in all 50 states.

Free Confidential Case Evaluation: Again, if you developed kidney disease, renal failure or nephritis after taking Nexium, you should contact our law firm immediately. You may be entitled to compensation by filing a lawsuit and we can help.

U.K. Issues Proton Pump Inhibitor (PPI) Bone Fracture Warnings

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U.K. health regulators have issued two new warnings to the public stating that the use of proton pump inhibitor (PPI) heartburn drugs may cause bone fractures, and have the potential to lead to dangerously low levels of magnesium in the body. According to the warnings, these risks are increased if high doses of PPIs are taken over long periods of time, and appear to primarily affect the elderly. Heartburn drugs belonging to the PPI class include Nexium, Prilosec, Protonix, Prevacid, Aciphex, Dexilant, Vimovo and Zegerid.

What’s the problem?

April 25, 2012 – During the month of April, the United Kingdom’s Medicines and Healthcare Products Regulatory Agency (MHRA) issued two separate warnings regarding proton pump inhibitor heartburn medications. The first warning stated that new evidence indicates an increased risk of hip, spine and wrist fractures associated with PPI use. The MHRA advised patients taking the medications to be sure they are getting enough calcium and vitamin D in their diets to reduce the bone fracture risk.

The other warning involved severe cases of magnesium deficiency (also known as hypomagnesaemia) which have been increasingly linked to PPIs. According to the statement, magnesium deficiency is associated with long-term use of the drugs at high doses. This evidence came from a review of adverse event reports sent to health authorities across Europe. In severe cases, hypomagnesaemia can cause fatigue, delirium, convulsion, dizziness, and other serious side effects.

Proton pump inhibitors are designed to reduce the amount of acid in the stomach, and are generally prescribed to treat the following conditions:

  • gastroesophageal reflux disease (GERD)
  • heartburn
  • ulcers in the stomach and small intestines
  • inflammation of the esophagus

In May 2010, the U.S. Food & Drug Administration (FDA) issued a warning stating that there may be an increased risk of bone fractures from PPI heartburn medications. The warning was updated a year later with an indication that this risk was linked to high doses of the drugs taken over prolonged periods of time. According to the FDA, this risk does not apply to over-the-counter PPIs.

The consumer watchdog group Public Citizen has petitioned the FDA to require black box warnings to be added to PPI labels, alerting users that the drugs have been linked to bone fractures and can cause dependency in a relatively short period of time.

Over the past several years, a growing number of PPI bone fracture lawsuits have been filed in courthouses around the country. The claims allege that drugmakers failed to adequately research their drugs and neglected to warn the public about the risk of bone fractures.

Nexium & Prilosec Bone Fracture Lawsuit Filed Against AstraZeneca

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A lawsuit has been filed against AstraZeneca on behalf of a woman who allegedly suffered catastrophic foot fractures after taking Nexium (esomeprazole) and Prilosec (omeprazole).

Free Confidential Lawsuit Evaluation: If you or a loved one suffered kidney damage after taking Nexium or Prilosec, you should contact our law firm immediately. You may be entitled to compensation by filing a suit against the manufacturer and our lawyers can help.

Update: Studies Link PPIs to Kidney Problems

A pair of recent studies have linked proton pump inhibitor (PPI) heartburn medications like Nexium and Prilosec to severe, potentially life-threatening kidney problems:

What’s the problem?

July 14, 2011 – The new product liability claim, which was filed against AstraZeneca on behalf of Susan A. Poznavich in New Jersey Superior Court in Bergen County, alleges that the woman suffered a number of severe foot fractures after taking Nexium and Prilosec, popular heartburn drugs that have garnered extensive media coverage recently after being linked to an increased risk of bone problems.

Poznavich’s claim is just one of a growing number of lawsuits filed by Nexium and Prilosec users in recent months. In May 2011, a claim was filed on behalf of 35 people in Texas who allegedly suffered bone deterioration and fractures after taking Nexium. The lawsuit was filed in Harris County District Court against AstraZeneca and a Houston-area sales manager, claiming that despite having knowledge of the side effects associated with the drug, Nexium was marketed and sold to the public without adequate warnings for consumers. According to the suit, Nexium caused various injuries to the plaintiffs including fractures of the foot, ankle, leg, arm, hand, knee and vertebrae.

Proton Pump Inhibitors (PPIs)

Nexium (esomeprazole) and Prilosec (omeprazole) belong to a class of drugs known as proton pump inhibitors (PPIs), whose main action is a pronounced and long-lasting reduction of gastric acid production. PPIs are extremely popular and widely used, with doctors writing nearly 115 million prescriptions for the medications each year nationwide. Nexium is AstraZeneca’s best selling prescription drug, as well as the third best-selling medication in the world, with over $5.2 billion in sales in 2008 alone. In May 2010, the U.S. Food & Drug Administration (FDA) warned that there may be an increased risk of bone fractures from these drugs. In March 2011, the administration updated its Nexium bone fracture warning, highlighting the fact that the risk of broken bones appears to be linked to high doses of the drugs used over an extended period of time.

Side Effects of Nexium & Prilosec

Studies have shown that the use of PPI medications like Nexium and Prilosec may greatly increase the risk of a number of side effects including:

  • chronic kidney disease (CKD)
  • nephritis (inflammation of the kidneys)
  • renal failure (end-stage renal disease or ESRD)
  • bone fractures
  • abdominal pain
  • constipation
  • nausea
  • diarrhea
  • stroke
  • allergic reactions
  • heart attack
  • weight loss
  • erectile dysfunction (ED)

Nexium & Prilosec FDA Warning

In May 2010, the FDA issued a press release stating that it was requiring the labels of PPI drugs like Nexium and Prilosec to be revised. The press release informed the public that PPIs may increase the risk of wrist, hip and spine fractures. In the announcement, the FDA advised users and doctors to weigh the benefits vs. risks of these medications closely before beginning a regimen.

Do I have a Nexium Lawsuit?

The Pharmaceutical Litigation Group at our law firm is an experienced team of trial lawyers that focus on the representation of plaintiffs in Nexium and Prilosec lawsuits. We are handling individual litigation nationwide and currently accepting new kidney failure cases in all 50 states.

Free Confidential Case Evaluation: Again, if you suffered kidney damage after taking Nexium or Prilosec, you should contact our law firm immediately. You may be entitled to a settlement by filing a suit and we can help.

Dexilant Lawsuit

Dexilant 60mg

The proton pump inhibitor (PPI) heartburn medication Dexilant has been linked to long-term kidney damage and other serious side effects, a recent study suggests.

Free Confidential Lawsuit Evaluation: If you or a loved one has been injured by Dexilant, you should contact our law firm immediately. You may be entitled to compensation by filing a suit against the manufacturer and our lawyers can help.

Study Links PPIs and Kidney Damage, End-Stage Renal Disease (ESRD)

April 14, 2016 – A new study has strengthened prior research suggesting an association between proton pump inhibitor heartburn medications like Dexilant and long-term kidney damage.

“This is very important from an epidemiologic point of view and also from a clinical perspective,” said study author Ziyad Al-Aly, MD, of the Clinical Epidemiology Center, VA Saint Louis Health Care System. “We also show that risk increases with increased duration of exposure. The constellation of findings suggests a strong and intimate link between PPI use and untoward kidney outcomes.”

Overview

Dexilant (generic: dexlansoprazole) is used to treat stomach and esophagus problems such as gastroesophageal reflux disease (GERD). The drug works by decreasing the amount of acid the stomach produces, thereby relieving symptoms such as heartburn, difficulty swallowing and persistent cough. Dexlansoprazole was originally marketed under the trade name Kadipex, which was changed in March 2010 to avoid confusion with 2 other medications – Casodex and Kadian.

Heartburn Medications & Kidney Disease

People who use PPIs like Dexilant have a 20-50% increased risk of developing chronic kidney disease (CKD), according to a January 2016 study published in JAMA Internal Medicine. The study doesn’t confirm a direct cause-and-effect relationship between PPIs and CKD; however, according to the study’s authors, “We found there was an increasing risk associated with an increasing dose. That suggests that perhaps this observed effect is real.” Over time, chronic kidney disease can lead to kidney failure, requiring the patient to undergo regular dialysis and possibly a kidney transplant, according to the U.S. National Institutes of Health (NIH).

Kidney Disease Symptoms

  • Weight loss / poor appetite
  • Swollen ankles, feet or hands 
  • Shortness of breath
  • Blood or protein in your urine 
  • Increased urination
  • Insomnia
  • Itchy skin
  • Muscle cramps
  • High blood pressure (hypertension)
  • Nausea
  • Erectile dysfunction (ED)

Bone Fractures

According to new data from an ongoing Nurses’ Health Study, the side effects of Dexilant and other PPI drugs increase the risk of bone fractures, particularly among women who smoke. The study began focusing on bone fractures in 1982, and includes some 238,000 participants. Researchers found that women who smoke or used to smoke and regularly took a PPI had a 51% increased risk of suffering a hip fracture. Women who did not smoke only had a 6% increased risk when taking a PPI. The new study is just the latest in a series of independent and government research that has linked an increased risk of bone fractures to PPI medications like Dexilant.

The severity of the bone fracture depends on a variety of factors including the propensity to fall, visual acuity, response to falling and bone strength. Bone mass is the single most important factor in determining bone strength, and accounts for up to 80% of its variance. Fracture sites, on the other hand, are typically age related. Wrist fractures are common for people in their fifties, while those in their sixties are most susceptible to spine fractures. By the time an individual reaches their seventies, the hip becomes the most common site of osteoporotic fracture.

FDA Warning

In May 2010, the FDA issued a safety announcement stating that it was revising the labels of PPI drugs. The warning alerted patients that this class of drugs may increase the risk of wrist, hip and spine fractures. In the press release, the administration advised users and their doctors to weigh the known benefits of these medications against the significant risks. The following statement illustrates the dangers associated with Dexilant and other PPI’s:

“Epidemiology studies suggest a possible increased risk of bone fractures with the use of proton pump inhibitors for one year or longer, or at high doses,” said Dr. Joyce Korvick, FDA’s Division of Gastroenterology Products deputy director for safety. “Because these products are used by a great number of people, it’s important for the public to be aware of this possible increased risk and, when prescribing proton pump inhibitors, health care professionals should consider whether a lower dose or shorter duration of therapy would adequately treat the patient’s condition.”

Side Effects of Dexilant

Proton pump inhibitor drugs like Dexilant may increase the risk of the following serious side effects:

  • Acute interstitial nephritis (inflammation of the kidneys)
  • Acute kidney injury
  • Chronic kidney disease (CKD)
  • Kidney failure (renal failure)
  • Cardiac disorders
  • Heart attack
  • Stroke
  • Bone fractures (hip fracture, wrist fracture, spine fracture)
  • Broken bones
  • Low magnesium levels (hypomagnesemia)
  • Gut infections
  • Dementia
  • Erectile dysfunction (ED) in men
  • Severe allergic reactions
  • And more

If You Are Taking Dexilant

Since heartburn is often confused with the first symptoms of a heart attack, seek immediate medical attention if you have chest pain or pain spreading to the arm or shoulder. You should not take Dexilant if you have a family history of liver disease or low levels of magnesium in your blood. Tell your doctor if you have osteoporosis or osteopenia (low bone mineral density). Dexilant is currently classified as a Pregnancy Category B medication, meaning that it is not expected to cause birth defects. Do not use Dexilant if you are breast feeding a baby, as the drug may pass into breast milk and could harm a nursing child.

Do I have a Dexilant Lawsuit?

The Pharmaceutical Litigation Group at our law firm is an experienced team of trial lawyers that focus on the representation of plaintiffs in Dexilant lawsuits. We are handling individual litigation nationwide and currently accepting new injury and death cases in all 50 states.

Free Confidential Case Evaluation: Again, if you were harmed by Dexilant side effects, you should contact our law firm immediately. You may be entitled to a settlement by filing a lawsuit and we can help.

Nexium Bone Fracture Lawsuit Filed by 35 in Texas

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June 1, 2011 – A new lawsuit has been filed against AstraZeneca on behalf of 35 Texas residents who claim to have suffered from unexpected bone fractures and deterioration after using Nexium, the company’s best-selling heartburn medication. According to the claim, Nexium caused various injuries including fractures of the foot, ankle, leg, arm, hand, knee and vertebrae. Since 2006, studies have suggested that Nexium may block the body’s ability to absorb calcium, which speeds up bone loss and leads to an increased number of fractures.

What’s the problem?

The new Nexium lawsuit was filed last week in Harris County District Court against pharmaceutical giant AstraZeneca and a Houston-area sales manager, claiming that despite having knowledge of the side effects associated with the drug, Nexium was marketed and sold to the public without adequate warnings for consumers. The complaint was filed on behalf of 34 women and one nine-year-old boy who experienced adverse side effects after taking the heartburn medication.

Included in the complaint are reports of foot, ankle, leg, arm, hand, knee and vertebrae fractures. A number of the plaintiffs suffered these injuries with no external trauma, resulting in surgery or permanent disability in many cases. Additionally, bone density scans revealed extensive bone deterioration and osteoporosis in many of the plaintiffs, despite having no family history of the conditions.

First approved by the U.S. Food & Drug Administration (FDA) in 2001, Nexium is a proton pump inhibitor (PPI) drug designed to decrease the amount of acid in the stomach. The drug is most often prescribed to treat gastroesophageal reflux disease (GERD), but is also commonly used to treat other conditions involving excessive stomach acid. Nexium is AstraZeneca’s best selling drug, as well as the third best selling medication in the world with over $5 billion in sales in 2008 alone.

FDA Warning on Nexium

In May 2010, the FDA issued a press release warning of the increased risk of bone fractures from Nexium and other PPI drugs including Aciphex, Prevacid, Prilosec, Protonix, Vimovo and Zegerid. In the announcement, the administration said that it was requiring an update to the warning labels of these medications reflecting the new information about bone fracture risks. Then in March 2011, the FDA again updated its Nexium bone fracture warning, stating that the side effects were associated with high doses of the drugs over a long period of time.

Proton Pump Inhibitor (PPI) Lawsuit

Proton Pump Inhibitors

Proton pump inhibitor (PPI) medications are commonly prescribed to individuals with heartburn and acid reflux disease. These drugs work by blocking acid buildup in the stomach. However, they also inhibit the absorption of vital minerals, which may lead to serious side effects including chronic kidney disease (CKD), heart attack, bone fractures and more.

Free Confidential Lawsuit Evaluation: If you or a loved one developed kidney disease, nephritis, renal failure or other kidney damage after taking a proton pump inhibitor (PPI) heartburn medication, you should contact our law firm immediately. You may be entitled to compensation by filing a suit against the manufacturer and our lawyers can help.

Update: PPIs Inappropriately Prescribed with Steroids, Study Finds

April 13, 2016 – PPI prophylaxis is routinely — and unnecessarily — recommended for patients taking corticosteroids without concomitant NSAID use, according to a study published this week in JAMA Internal Medicine. Researchers found that these prescriptions are not only inappropriate, based on a review of literature indicating that peptic ulcers are not a cause of concern in this scenario, but also potentially dangerous to the patient. Among other outcomes, proton pump inhibitor hypersensitivity can lead to angiodema, anaphylaxis, drug reaction with eosinophilia and systemic symptoms (DRESS), and cutaneous reactions.

What are Proton Pump Inhibitors (PPIs)?

PPIs are widely prescribed for the treatment of various acid-peptic disorders including gastroesophageal reflux disease (GERD), peptic ulcer disease, and nonsteroidal anti-inflammatory drug­induced gastropathy. These drugs work by reducing the production of acid by blocking the enzyme in the wall of the stomach that produces acid. This reduction of acid prevents ulcers and allows any existing ulcers to heal.

PPI Drug List

What’s the Problem?

Long-term use of PPI medications may cause problems with the body’s ability to absorb calcium, magnesium and other vital nutrients. Patients who take the drugs for an extended period of time (typically over one year) are at risk of suffering kidney damage, bone fractures / breaks and other serious side effects.

Proton Pump Inhibitor (PPI) Side Effects

  • Acute interstitial nephritis (inflammation of the kidneys)
  • Acute kidney injury
  • Chronic kidney disease (CKD)
  • Kidney failure (renal failure)
  • Cardiac disorders
  • Heart attack
  • Stroke
  • Bone fractures (hip fracture, wrist fracture, spine fracture)
  • Broken bones
  • Low magnesium levels (hypomagnesemia)
  • Gut infections
  • Dementia
  • Erectile dysfunction (ED)
  • Severe allergic reactions
  • And more

PPIs and Kidney Disease

Due to their ability to block the secretion of acid into the stomach, proton pump inhibitors may increase the risk of chronic kidney disease, according to a January 2016 study published in JAMA Internal Medicine. For the study, researchers looked at the medical records of over 10,000 patients treated in community-based settings, and found a 20-50% increased risk of kidney disease among than those who did not take them. The association also turned up when they examined the records of more than 248,000 people treated in a Pennsylvania hospital system.

Bone Fractures

On May 25, 2010, the U.S. Food & Drug Administration (FDA) published information regarding the increased risk of fractures of the hip, wrist, and spine with high doses or long-term use of PPIs. The product labeling on such medications was ordered to be changed to describe this possible increased risk. The Administration’s decision to revise the labeling of PPIs was reportedly based on the review of several epidemiological studies that reported an increased risk of fractures of the hip, wrist and spine in patients using proton pump inhibitors.

Do I have a Proton Pump Inhibitor Lawsuit?

The Pharmaceutical Litigation Group at our law firm is an experienced team of trial lawyers that focus on the representation of plaintiffs in proton pump inhibitor lawsuits. We are handling individual litigation nationwide and currently accepting new kidney damage cases in all 50 states.

Free Confidential Case Evaluation: Again, if you suffered any form of kidney damage after taking a proton pump inhibitor heartburn drug, you should contact our law firm immediately. You may be entitled to a settlement by filing a suit and we can help.

Zegerid Lawsuit

Zegerid

Users of the heartburn medication Zegerid may be at an increased risk of developing serious side effects including kidney failure, heart attack, bone fractures and more.

Free Confidential Lawsuit Evaluation: If you or a loved one was injured by Zegerid side effects, you should contact our law firm immediately. You may be entitled to compensation by filing a suit against the manufacturer and our lawyers can help.

Update: Kidney Damage, PPIs Linked in New Study

April 14, 2016Proton pump inhibitor (PPI) acid reflux drugs like Zegerid could be increasing rates of chronic kidney disease (CKD) and renal failure, according to a study published today in the Journal of the American Society of Nephrology (JASN). The researchers looked at data from the Department of Veterans Affairs national databases. They found more than 170,000 new users of PPIs and compared them to over 20,000 new users of histamine H2 receptor blockers, another class of medication used to reduce stomach acid.

Over 5 years of follow-up, the results showed that 15% of PPI users were diagnosed with kidney disease, compared to 11% of those on H2-blockers. After controlling for other factors, including age and other diseases, this translated to a 28% increased risk of CKD for proton pump inhibitor users.

Overview

Zegerid (omeprazole / sodium bicarbonate) is a proton pump inhibitor (PPI) heartburn medication used to treat acid reflux disease. It is also less commonly prescribed to treat erosive esophagitis, active duodenal ulcers and active benign gastric ulcers. A nonprescription version – Zegerid OTC – is also available for the short treatment of frequent heartburn. Prescription Zegerid capsules are made by Norwich Pharmaceuticals, Inc., for Santarus, Inc.

Proton Pump Inhibitors Linked to Kidney Disease: JAMA Study

The use of PPI heartburn medications like Zegerid is associated with chronic kidney disease (CKD), according to a study published Jan. 11, 2016 in JAMA Internal Medicine. Among 10,482 test subjects, PPI use was associated with a 45% increased risk of CKD compared to patients who did not take the medications. When the figures were adjusted for demographics, socioeconomic and clinical variables, a 50% increased risk was detected.

Zegerid Side Effects

  • Acute interstitial nephritis (inflammation of the kidneys)
  • Acute kidney injury
  • Chronic kidney disease (CKD)
  • Kidney failure (renal failure)
  • Heart attack
  • Bone fractures (hip fracture, wrist fracture, spine fracture)
  • Broken bones
  • Low magnesium levels (hypomagnesemia)
  • Gut infections
  • Dementia
  • And more

Zegerid should not be taken by people with a hypersensitivity to omeprazole or sodium bicarbonate. Women who are pregnant or planning to become pregnant should discuss Zegerid with their healthcare professional prior to taking the medication. To date, there have been no clinical studies on the effects of Zegerid in pregnant women and nursing mothers.

Bone Fractures

In May 2010, the U.S. Food & Drug Administration (FDA) required that additional information be provided about the risk of Zegerid bone fractures on its packaging as well as the packaging of other similar heartburn medications. The Administration stated that all proton pump inhibitor medications will now include a warning that they may increase the risk of fracturing bones in the hips, wrist, and spine.

“Epidemiology studies suggest a possible increased risk of bone fractures with the use of proton pump inhibitors for one year or longer, or at high doses,” said Dr. Joyce Korvick, FDA’s Division of Gastroenterology Products deputy director for safety. “Because these products are used by a great number of people, it’s important for the public to be aware of this possible increased risk and, when prescribing proton pump inhibitors, health care professionals should consider whether a lower dose or shorter duration of therapy would adequately treat the patient’s condition.”

FDA’s decision to revise the labeling of proton pump inhibitors was based on the Agency’s review of several epidemiological studies that reported an increased risk of fractures of the hip, wrist and spine in patients using PPIs. Both the Warnings and Precautions section of the prescription labeling and the Drug Facts label on OTC proton pump inhibitors will address these findings.

Do I Have a Zegerid Lawsuit?

The Pharmaceutical Litigation Group at our law firm is an experienced team of trial lawyers that focus on the representation of plaintiffs in Zegerid lawsuits. We are handling individual litigation nationwide and currently investigating potential settlements in all 50 states.

Free Confidential Case Evaluation: Again, if you were injured by the side effects of a heartburn medication, you should contact our law firm immediately. You may be entitled to a settlement by filing a lawsuit and we can help.