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Proton Pump Inhibitors Linked to Rhabdomyolysis: Study

A new case study has found that use of proton pump inhibitor heartburn medications may increase the risk of rhabdomyolysis, a condition in which skeletal muscle breaks down rapidly.

A new case study has found that use of proton pump inhibitor (PPI) heartburn medications like Nexium (esomeprazole) and Prilosec (omeprazole) may increase the risk of rhabdomyolysis, a condition in which skeletal muscle breaks down rapidly.

Free Confidential Lawsuit Evaluation: If you or a loved one suffered kidney damage after taking a proton pump inhibitor, you should contact our law firm immediately. You may be entitled to compensation by filing a suit against the manufacturer and our lawyers can help.

What’s the Problem?

September 26, 2016 – The case report, which was published last month in the journal Medicine, described a patient who developed rhabdomyolysis after a single intravenous dose of Nexium.

The patient was a 45-year-old man who was hospitalized for persistent lower chest pain. He had been previously diagnosed with type 2 diabetes and coronary heart disease, but had stopped taking his diabetes medications about one month prior to being hospitalized. He was still taking his heart disease medicine.

Doctors administered 40 mg of Nexium to help control his chest pain, but 12 hours later he began complaining about severe pain in his right buttock. Doctors found that the muscles in the area had become swollen and tender. A blood test determined that the patient’s levels of creatine kinase (an enzyme associated with muscle damage) and lactate dehydrogenase (an enzyme associated with tissue damage) were elevated. Doctors then performed a bone scan which revealed that he had developed rhabdomyolysis.

Rhabdomyolysis Symptoms

Rhabdomyolysis is characterized by the breakdown of muscle tissue that causes muscle fiber contents to be released into the blood. These substances are harmful to the kidneys and can lead to kidney damage, a side effect that has been well-documented and repeatedly linked to the use of proton pump inhibitors. Signs and symptoms of rhabdomyolysis include:

  • Dark, red or cola-colored urine
  • Decreased urine output
  • General weakness
  • Muscle stiffness or aching (myalgia)
  • Muscle tenderness
  • Weakness of the affected muscles

Treatment

Patients with rhabdomyolysis will be administered fluids containing bicarbonate to help prevent kidney damage. Some patients may require kidney dialysis. Medicines including diuretics and bicarbonate may also be prescribed.

Do I Have a Proton Pump Inhibitor Lawsuit?

The Pharmaceutical Litigation Group at our law firm is an experienced team of trial lawyers that focus on the representation of plaintiffs in PPI lawsuits. We are handling individual litigation nationwide and currently accepting new kidney injury cases in all 50 states.

Free Case Evaluation: Again, if you were injured by the side effects of a proton pump inhibitor, you should contact our law firm immediately. You may be entitled to a settlement by filing a suit and our lawyers can help.

Free Confidential Case Evaluation

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