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PPI Heartburn Medicines Linked to Rare Dermatological Reactions

PPIs Protonix and Prevacid linked to rare skin reactions granulomatous dermatitis and lichenoid dermatosis.

Proton pump inhibitor (PPI) heartburn medications have been linked to 2 severe dermatological skin reactions, according to a case report presented at this year’s American College of Gastroenterology meeting.

Free Confidential Lawsuit Evaluation: If you or a loved one was injured by the side effects of a heartburn medicine, you should contact our law firm immediately. You may be entitled to compensation by filing a suit and our lawyers can help.

What’s the Problem?

October 23, 2017 – The case involved a 32-year-old man who was prescribed pantoprazole — the active ingredient in Protonix — after presenting with dyspepsia-like symptoms. Within days of starting treatment with the drug, he claims to have developed a rash on his face, neck and trunk, which was subsequently diagnosed as acneiform eruption.

The patient was treated with topical creams, oral doxycycline, and prednisone; however, these therapies were ineffective. A skin biopsy revealed that he had granulomatous dermatitis.

Test subject continued to suffer from abdominal pain, with subsequent testing confirming an H. pylori infection, which was treated with a regimen of lansoprazole (Prevacid), amoxicillin and clarithromycin. These therapies were also unsuccessful, as the patient developed a worsening rash on his face and neck, with the acneiform nodules spreading to his extremities.

This regimen was discontinued, and a second skin biopsy indicated “lichenoid dermatosis with lymphocytes obscuring the dermo-epidermal junction, associated with necrotic keratinocytes.”

The rash eventually went away after treatment was discontinued; however, the acneiform eruption continued and required isotretinoin to treat.

Test subject was then started on a regimen of ranitidine, amoxicillin, clarithromycin, and metronidazole to treat his H. pylori infection.

The authors of the case study highlight 2 specific reactions to PPIs: granulomatous dermatitis to pantoprazole and lichenoid dermatosis to lansoprazole.

“Unique in this case is the persistence and severe sequelae of the acneiform lesions months after withdrawal of the offending agent,” the researchers concluded.

Do I Have a PPI Lawsuit?

The Pharmaceutical Litigation Group at our law firm is an experienced team of trial lawyers that focus on the representation of plaintiffs in proton pump inhibitor lawsuits. We are handling individual litigation nationwide and currently accepting new injury and death cases in all 50 states.

Free Case Evaluation: Again, if you were harmed by heartburn drug side effects, you should contact our law firm immediately. You may be entitled to a settlement by filing a suit and we can help.

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