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Meta Analysis: Pradaxa Bleeding Risk Outweighs Benefits

According to the results of a new study, the risk of uncontrollable internal bleeding events with Pradaxa and other blood thinners may cancel out any possible health benefit offered by the drugs.

September 29, 2012 – According to the results of a new study published in the Archives of Internal Medicine, the risk of uncontrollable internal bleeding events with Pradaxa and other newer-generation blood thinners may cancel out any possible health benefit offered by the drugs. 

Free Pradaxa Lawsuit Evaluation: If you or a loved one has been injured by Pradaxa, you should contact our law firm immediately. You may be entitled to compensation by filing a suit against the manufacturer and our lawyers can help.

For the new report, European researchers conducted a seven-study meta analysis of internal bleeding episodes linked to blood-thinning medications known as Xa inhibitors and direct thrombin inhibitors. The team analyzed databases of research conducted on individuals who were treated with these types of drugs after suffering acute coronary syndrome (ACS), and looked at placebo-controlled clinical trials that included more than 30,000 test subjects. The researchers ultimately identified a three-fold risk of internal bleeding events, but only marginal reductions in the risk of additional heart problems and no tangible benefit for the patient in terms of overall long-term survival outlook.

“For the net clinical benefit, treatment with new-generation oral anticoagulant agents provided no advantage over placebo,” the authors of the report concluded. “The use of anti-Xa or direct thrombin inhibitors is associated with a dramatic increase in major bleeding events, which might offset all ischemic benefits in patients receiving antiplatelet therapy after an ACS.”

Of all the direct thrombin inhibitors currently available, Boehringer Ingelheim’s Pradaxa (generic: dabigatran) is by far the most widely-prescribed. Yet despite being on the market for less than three years, serious concerns have been raised over the risk of internal bleeding problems with the drug, which have resulted in a large number of deaths and other catastrophic injuries.

As a result of these complications, a growing number of Pradaxa lawsuits are being filed in courthouses around the country on behalf of individuals who have been severely injured or killed after being treated with the drug. While there are only about 50 Pradaxa lawsuits currently pending on the federal level, industry insiders have predicted that this number will grow significantly in the near future. All federal Pradaxa lawsuits have been consolidated into a multidistrict litigation (MDL) before Judge David R. Herndon in the Southern District of Illinois for pretrial handling.

Do I Have a Pradaxa Lawsuit?

The Product Liability & Defective Drug Litigation Group at our law firm is an experienced team of trial lawyers that focus on the representation of plaintiffs in Pradaxa lawsuits. We are handling individual litigation nationwide and currently accepting new cases in all 50 states.

Free Confidential Case Evaluation: Again, if you or a loved one was injured by Pradaxa, you should contact our law firm immediately. You may be entitled to compensation by filing a Pradaxa Suit and our lawyers can help.

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