Long-term use of proton pump inhibitor (PPI) heartburn drugs has again been linked to an increased risk for chronic kidney disease (CKD) and kidney failure, according to a new study.
Free Confidential Lawsuit Evaluation: If you or a loved one was injured by the side effects of a proton pump inhibitor, you should contact our law firm immediately. You may be entitled to compensation by filing a suit against the manufacturer and our lawyers can help.
What’s the Problem?
April 14, 2016 – The study, published online today in the Journal of the American Society of Nephrology (JASN), reinforces prior research which suggests that PPI heartburn drugs can cause severe kidney damage. Proton pump inhibitors include:
- Nexium (esomeprazole magnesium)
- Aciphex (rabeprazole)
- Protonix (pantoprazole)
- Prevacid (lansoprazole)
- Zegerid (omeprazole / sodium bicarbonate)
- Dexilant (dexlansoprazole)
- Prilosec (omeprazole)
For the new study, researchers looked at data from the Department of Veterans Affairs (DVA) national databases. They found more than 170,000 new proton pump inhibitor users and compared them to over 20,000 patients who took histamine H2 receptor blockers (Pepcid, Tagamet, Zantac), another class of heartburn drug used to suppress stomach acid.
After 5 years of follow-up, the results indicated that 15% of PPI users developed chronic kidney disease (CKD), versus 11% of those who took H2-blockers. After calculating for variables including age and other diseases, this equaled a 28% increased risk of CKD for proton pump inhibitor users.
Only a few patients in the study (>0.2%) developed end-stage renal disease (ESRD), but the risk was 96% higher for those on PPIs.
The study’s authors were careful to point out that the research shows an association, and does not prove a cause and effect relationship, and that other factors may be influencing the outcomes. However, they note that the results highlight an important point: “[patients should] use PPIs only when it is medically necessary, and should limit duration of exposure to the minimum necessary to treat the underlying medical condition,” said lead author Dr. Ziyad Al-Aly of the Clinical Epidemiology Center at the VA Saint Louis Health Care System.
Do I Have a Proton Pump Inhibitor Lawsuit?
The Pharmaceutical Litigation Group at our law firm is an experienced team of trial lawyers that focus on the representation of plaintiffs in PPI lawsuits. We are handling individual litigation nationwide and currently accepting new kidney damage cases in all 50 states.
Free Confidential Case Evaluation: Again, if you or a loved one suffered kidney damage after taking a proton pump inhibitor, you should contact our law firm immediately. You may be entitled to compensation by filing a suit and we can help.