Proton pump inhibitors (PPIs) have been linked to an increased risk for heart failure and death in patients with coronary artery disease (CAD), according to a new study.
Free Confidential Lawsuit Evaluation: If you or a loved one was injured by the side effects of a proton pump inhibitor (PPI) heartburn medication, you should contact our law firm immediately. You may be entitled to compensation by filing a suit and our lawyers can help.
What’s the Problem?
March 23, 2017 – The study, which was published Jan. 19 in the journal PLOS ONE, found that chronic antiplatelet therapy (aspirin, Plavix, Effient) in patients with coronary artery disease carries the risk for gastrointestinal complications including ulcers, hemorrhage and gastric erosions.
Proton pump inhibitors are commonly used to prevent or treat these complications; however, use of the drugs may cause pneumonia, micronutrient deficiencies, and osteoporosis-related fractures, according to the study.
- Nexium (esomeprazole magnesium)
- Aciphex (rabeprazole)
- Protonix (pantoprazole)
- Prevacid (lansoprazole)
- Zegerid (omeprazole / sodium bicarbonate)
- Dexilant (dexlansoprazole)
- Prilosec (omeprazole)
- Vimovo (esomeprazole and naproxen)
Limited data suggests that use of these medications could inhibit the antiplatelet effect of aspirin and clopidogrel and lead to more cardiovascular events in CAD patients.
For the study, researchers looked at a cohort of 706 patients, 431 of whom took proton pump inhibitors (most commonly omeprazole). Approximately two-thirds of the patients were taking clopidogrel, and over 90% were taking aspirin.
The study found that PPI use increased the risk for all-cause heart failure or death (HR, 5.713; P =.007), but not for acute ischemic events.
“In conclusion, our results suggest an association between use of PPIs and the incidence of death or [heart failure] but do not point to an association with incidence of acute ischemic events,” the researchers concluded. “More studies are needed to confirm these data.”
Do I Have a PPI Lawsuit?
The Pharmaceutical Litigation Group at our law firm is an experienced team of trial lawyers that focus on the representation of plaintiffs in proton pump inhibitor lawsuits. We are handling individual litigation nationwide and currently accepting new injury and death cases in all 50 states.
Free Case Evaluation: Again, if you were injured by the side effects of a proton pump inhibitor, you should contact our law firm immediately. You may be entitled to a settlement by filing a suit and we can help.