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Permax Lawsuit

Permax (pergolide) has been linked to the development of heart valve problems, leg & foot swelling, as well as a number of other adverse side effects. In a public health advisory, the U.S. Food & Drug Administration (FDA) urged patients still taking Permax to contact their healthcare providers immediately to discuss possible treatment alternatives. The Defective Drug Litigation Group at Schmidt & Clark, LLP is handling individual litigation nationwide and currently accepting new Permax cases in all 50 states.

Free Permax Case Evaluation: If you or a loved one has developed any harmful side effects after taking Permax, you should contact our law firm immediately. You may be entitled to compensation by filing a lawsuit and we can help.

What’s the problem?

Permax is a prescription medication used to manage the symptoms of Parkinson’s disease. It is commonly used in conjunction with levodopa in order to maximize its effectiveness, and has also been used off-label to treat Restless Legs Syndrome (RLS). Over the past several years, however, the use of Permax has been shown to significantly increase the risk of cardiac valvular disease involving one or more valves. Certain individuals have required valve replacement, and a number of deaths have even occurred. Cases have been reported after exposures to Permax ranging from just a few months to several years.

Permax Heart Valve Disease Study

A 2007 study published in the New England Journal of Medicine (NEJM) concluded that Permax and Dostinex caused the same type of heart damage that led to the withdrawal of the notorious diet drug fen-phen. According to the NEJM report:

“Several studies and case reports strongly support a causal relationship between the occurrence of drug-induced “restrictive” valvular heart disease and treatment with pergolide, an ergot-derived dopamine receptor agonist mainly used to treat Parkinson’s disease. More specifically, pergolide may induce fibrotic changes in valve leaflets and in the mitral subvalvular apparatus, causing thickening, retraction, and stiffening of valves and resulting in incomplete leaflet coaptation and valve regurgitation.”

Symptoms of Valve Disease

Signs and symptoms of Permax-induced heart valve disease can occur quickly if the onset of the condition is severe and sudden. If the disease develops slowly and the heart has time to adjust, one may barely notice symptoms. Symptoms include (but are not limited to):

  • Shortness of breath or difficulty catching your breath
  • Palpitations (rapid or irregular heart rate rhythms)
  • Swelling of the ankles, feet, or abdomen (edema)
  • Weakness or dizziness
  • Rapid weight fluctuation

Contact your healthcare provider immediately if you begin to have new symptoms or if they become more frequent or severe.

Do I have a Permax Lawsuit?

The Product Liability & Defective Drug Litigation Group at our law firm is an experienced team of trial lawyers that focus on the representation of plaintiffs in Permax lawsuits. We are handling individual litigation nationwide and currently accepting new valvular heart disease cases in all 50 states.

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