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Nexium Linked to Artery Damage: Study

A new study has found that the proton pump inhibitor heartburn medication Nexium may cause artery damage which could lead to an increased risk for kidney failure, heart attack and dementia.

A new study has found that the proton pump inhibitor (PPI) heartburn medication Nexium may cause artery damage which could lead to an increased risk for kidney failure, heart attack and dementia.

Free Confidential Lawsuit Evaluation: If you or a loved one suffered kidney damage after taking a proton pump inhibitor, you should contact our law firm immediately. You may be entitled to compensation by filing a suit against the manufacturer and our lawyers can help.

What’s the Problem?

June 6, 2016 – For the study, a research team led by John P. Cooke at the Houston Methodist Research Institute exposed endothelial cells — the cells that line the walls of arteries — to Nexium (esomeprazole magnesium), and compared the results to endothelial cells exposed to H2 blocker heartburn medications (Zantac, Pepcid, Tagamet).

The researchers found that cells exposed to H2 blockers showed no signs of aging, while the cells exposed to Nexium had a “fried egg” appearance. Due to the fact that proton pump inhibitors block acid production by impairing parts of cells called lysosomes, “garbage” builds up in the artery cells which causes them to age.

The study also found that vascular cells couldn’t divide or proliferate as well when exposed to Nexium. This makes it difficult for cells to repair wounds in blood vessels, and prevents them from performing tasks that can help prevent heart attack and stroke, according to the researchers.

“I’m perplexed that the pharmaceutical industry didn’t run across this first,” Cooke said. “This is something that should have been apparent a long time ago and should have been investigated.”

Additionally, the endothelial cells exposed to Nexium showed signs of shortening in chromosomes tips known as telomeres. Previous research has associated shortened telomeres to age-related conditions including dementia, cancer and heart disease.

“Our finding that the lining of blood vessels is impaired by proton pump inhibitors is a unifying mechanism for the reports that PPI users are at increased risk for heart attack, stroke and renal failure,” Cooke told the Chicago Tribune.

Cooke also said that one of the main problems with proton pump inhibitors is that patients rarely use them as directed. The U.S. Food & Drug Administration (FDA) has approved PPIs for use only for 4 weeks at a time, 3 times per year. Instead, many patients use the medications nearly constantly without ever taking a break.

Do I Have a Proton Pump Inhibitor Lawsuit?

The Pharmaceutical Litigation Group at our law firm is an experienced team of trial lawyers that focus on the representation of plaintiffs in PPI lawsuits. We are handling individual litigation nationwide and currently accepting new acute kidney injury cases in all 50 states.

Free Confidential Case Evaluation: Again, if you suffered kidney damage or renal failure after taking a PPI heartburn medication, you should contact our law firm immediately. You may be entitled to compensation by filing a suit and we can help.

Free Confidential Case Evaluation

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