Nephrogenic Fibrosing Dermopathy (NFD) Lawsuit

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Nephrogenic Fibrosing Dermopathy (NFD) is a serious, life-threatening skin disorder, which has recently been linked to the use of gadolinium-based contrast agents during MRI or MRA procedures.

What is Nephrogenic Fibrosing Dermopathy?

Nephrogenic Fibrosing Dermopathy (NFD), also known as Nephrogenic Systemic Fibrosis (NSF), is a skin condition that is often described as a swelling and tightening of the skin, usually limited to the extremities. The condition may develop over a short period of days or could take weeks to fully develop. Severely affected patients may be unable to walk, or fully extend the joints of their arms, hands, legs, and feet. Complaints of muscle weakness are common.

Signs and Symptoms of Nephrogenic Fibrosing Dermopathy

People that have developed Nephrogenic Fibrosing Dermopathy generally exhibit the following symptoms:

  • Burning
  • Itching
  • Swelling
  • Hardening and tightening of the skin
  • Red or dark patches on the skin
  • Yellow spots on the whites of the eyes
  • Stiffness in joints and trouble moving or straightening the arms, hands, legs, or feet
  • Pain deep in the hip bones or ribs
  • Muscle weakness

Treatment Options

According to The International Center for Nephrogenic Fibrosing Dermopathy Research (ICNFDR), “there is no consistently successful treatment for NFD, improving renal function (due to any modality) seems to slow or arrest NFD (and in many cases allows for gradual reversal of the process over time).”

Nephrogenic Fibrosing Dermopathy treatments that have been tried and continue to be investigated include:

  • Oral steroids (prednisone)
  • Topical Dovonex (under occlusion)
  • Extracorporeal photopheresis (ECP)
  • Plasmapheresis
  • Cytoxan
  • Thalidomide
  • Ultraviolet therapy
  • Physical therapy (PT)
  • Pentoxifylline (PXF)
  • High Dose Intravenous Ig Therapy
  • Renal transplantation

Nephrogenic Fibrosing Dermopathy & Gadolinium-Based Contrast Agents

UPDATE: Read the May 23, 2007 FDA press release, “FDA Requests Boxed Warning for Contrast Agents Used to Improve MRI Images.”

The U.S. Food and Drug Administration (FDA) has requested the manufacturers of gadolinium-based contrast agents to add a new boxed warning on the product labeling because of new reports linking the agents to a life-threatening skin disorder.

The requested boxed warning would state:

“Patients with severe kidney insufficiency who receive gadolinium-based agents are at risk for developing a debilitating, and a potentially fatal disease known as Nephrogenic Fibrosing Dermopathy (NFD). In addition, it would state that patients just before or just after liver transplantation, or those with chronic liver disease, are also at risk for developing NFD if they are experiencing kidney insufficiency of any severity.”

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