The diabetes drug Invokamet (canagliflozin and metformin) has been linked to serious side effects including diabetic ketoacidosis (DKA), kidney failure and an increased risk for amputations of the foot, legs and toes. This article answers some of the most frequently asked questions about Invokamet.
Free Confidential Lawsuit Evaluation:, you should contact our law firm immediately. You may be entitled to compensation by filing a suit against the manufacturer and our lawyers can help.
What is Invokamet?
Invokamet is made of a combination of canagliflozin and metformin, oral diabetes drugs that help regulate blood sugar levels. Canagliflozin works by helping the kidneys excrete glucose (sugar) from the body through urine, and metformin lowers glucose production in the liver and causes the intestines to absorb less glucose. Invokamet belongs to a newer class of type 2 diabetes medications called sodium-glucose co-transporter 2 (SGLT2) inhibitors.
Which Other Drugs are SGLT2 Inhibitors?
In addition to Invokamet, other type 2 diabetes medications in the SGLT2 inhibitor class include:
- Invokana (canagliflozin)
- Farxiga (dapagliflozin)
- Glyxambi (empagliflozin and linagliptin)
- Jardiance (empagliflozin)
- Xigduo XR (dapagliflozin and metformin hydrochloride extended-release)
Has Invokamet Been Linked to Side Effects?
Despite its considerable effectiveness as a treatment for type 2 diabetes, Invokamet has been linked to a large number of serious side effects including:
- Diabetic Ketoacidosis (DKA, Diabetic Acidosis, Metabolic Ketoacidosis, Ketoacidosis)
- Heart Attack (Myocardial Infarction or MI)
- Amputations of the foot, leg or toes
- Kidney Failure (Renal Failure)
- Kidney Cancer
- Kidney Infections (Pyelonephritis)
- Kidney Stones
- Bone Fractures
- Bone Abnormalities
- Testicular Cancer
- Urinary Tract Infections (UTIs)
- Severe Dehydration / Fluid Imbalance
- Abnormal Weight Loss
- Hypersensitivity (Allergic Response)
- Blood Infections (Urosepsis)
- Fungal Infections
Are There Other Side Effects?
Invokamet may also cause the following less severe side effects in certain users:
- Increased Urination
- Yeast Infections (both men and women)
- Vaginal Itching
- And more
What Does the FDA Say About Invokamet?
In May 2015, the U.S. Food & Drug Administration (FDA) warned that SGLT2 inhibitor diabetes drugs like Invokamet had been linked to diabetic ketoacidosis (DKA), a life-threatening condition that occurs when the body produces high levels of blood acids called ketones. Between March 2013 and June 6, 2014, at least 20 cases of ketoacidosis in patients treated with the drugs were reported to the agency. New verbiage describing the risk of DKA was added to SGLT2 inhibitor labels on December 4, 2015.
What About Amputations?
FDA issued another warning about SGLT2 inhibitors on May 18, 2016, this time regarding an increased risk for leg, foot and toe amputations. The warning followed interim results of the ongoing Canagliflozin Cardiovascular Assessment Study (CANVAS), which found that amputations occurred roughly twice as often in canagliflozin users compared to those who took a placebo.
Has There Been a Recall?
Despite being linked to severe, life-threatening side effects, neither Invokamet nor any other diabetes drug from the SGLT2 inhibitor class has been recalled in the U.S. It is important to remember that this is still a relatively new class of drugs, and it often takes many years and adverse event reports before enough information comes forward which could ultimately result in a recall.
Is There a Class Action?
To date, no class action has been filed over injuries allegedly caused by Invokamet, and our attorneys are doubtful that any such action will be entered in the future. However, if multiple lawsuits are filed alleging similar injuries from the drug, the cases may be consolidated into a multidistrict litigation (MDL) for discovery and pretrial handling. MDLs are distinct from class actions, and it is generally agreed that consolidating cases instead of proceeding in a class action is a more efficient way of handling claims arising from injuries caused by pharmaceutical products.
Are Cases Being Settled?
Invokamet is still a new drug, and the first lawsuits over the drug were only recently filed. Litigation like this often takes many years before the manufacturer considers settling some or all of the cases. Generally, individual, small or large group settlements do not occur until such time as a few cases (bellwether trials) are brought before a jury, and the manufacturer is able to more thoroughly understand its financial risk.
What are Invokamet Lawsuits Alleging?
Invokamet lawsuits allege that Janssen Pharmaceuticals knew or should have known about the risk of diabetic ketoacidosis, kidney failure, amputations and other serious side effects associated with the drug, but failed to adequately warn about these risks in an effort to protect their own profits.
What Damages Could I Recover?
If our lawyers determine that you have a legitimate claim against Janssen for an injury you suffered as a result of taking Invokamet, you may be eligible to receive compensation for medical expenses, lost wages, pain and suffering, and other damages. Punitive damages may also be awarded to deter bad actions on the part of possible future defendants and to make sure the defendant is appropriately punished for any wrongdoing.
Do I Have an Invokamet Lawsuit?
The Pharmaceutical Litigation Group at our law firm is an experienced team of trial lawyers that focus on the representation of plaintiffs in Invokamet lawsuits. We are handling individual litigation nationwide and currently accepting new injury and death cases in all 50 states.
Free Drug Lawsuit Evaluation: Again, if you or a loved one was injured by Invokamet side effects, you should contact our law firm immediately. You may be entitled to a settlement by filing a suit and we can help.