The above conditions result from long-term gadolinium retention in MRI patients’ brains and other vital organs, resulting in a myriad of symptoms including bone pain, skin and subcutaneous tissue burning pain, and “chemo brain” or “brain fog.”
Free Confidential Lawsuit Evaluation: If you or a loved one has suffered from gadolinium retention, you should contact our law firm immediately. You may be entitled to compensation by filing a suit and our lawyers can help.
What is Dotarem?
Dotarem is a gadolinium-based contrast agent (GBCA) used during magnetic resonance imaging (MRI) scans of the brain and spine in adults and children aged 2 years or older. When injected into the body, Dotarem enhances and improves the quality of the MRI images, which allows the radiologist to more accurately report on how your body is working and whether there is any disease or abnormality present.
What’s the Problem?
Recent studies have found that GBCAs like Dotarem have been shown to be deposited in the brain and to induce persistent T1 shortening in deep gray matter structures in subjects with normal renal function, according to La Radiologia Medica. The problem occurs when the gadolinium from GCBAs breaks apart into its free form before it can be expelled by urination, which can result in serious adverse reactions or side effects. This free-form gadolinium has been found in various parts of the human body, including the brain, bones, skin, and other pockets within the body.
What are the Symptoms of Gadolinium Retention?
Signs and symptoms of gadolinium deposition disease may include:
- Bone pain
- Joint pain
- Skin and subcutaneous tissue burning pain
- “Chemo brain” or “brain fog”
- Skin changes
- Thickening / discoloration of the skin
- “Pins and needles” in the arms and legs
In most patients, these symptoms tend to occur within hours to days of undergoing an MRI or other similar procedure involving use of gadolinium-based contrast agent administration (GBCAs).
Are There Other Side Effects?
In addition to increasing the risk of gadolinium retention (gadolinium storage condition / gadolinium deposition disease, Dotarem may cause the following side effects in some users:
- Nephrogenic Systemic Fibrosis (NSF)
- Difficulty breathing
- Cardiac arrest
- Swelling of the throat or other parts of the body
- Low blood pressure
- And more
FDA Warning on Gadolinium
In December 2017, FDA published a MedWatch Alert announcing that it was requiring the manufacturers of gadolinium contrast dyes to add new warnings to their labeling regarding an increased risk of gadolinium retention following MRIs and other similar medical procedures. However, the agency said it was unable to determine any long-term health effects from GCBAs, and affirmed the drugs’ risk vs. benefits profile.
“FDA is requiring several actions to alert health care professionals and patients about gadolinium retention after an MRI using a GBCA, and actions that can help minimize problems,” FDA sad. “These include requiring a new patient Medication Guide, providing educational information that every patient will be asked to read before receiving a GBCA. FDA is also requiring manufacturers of GBCAs to conduct human and animal studies to further assess the safety of these contrast agents.”
Do I Have a Dotarem Lawsuit?
The Pharmaceutical Litigation Group at our law firm is an experienced team of trial lawyers that focus on the representation of plaintiffs in Dotarem lawsuits. We are handling individual litigation nationwide and currently accepting new gadolinium injury cases in all 50 states.
Free Case Evaluation: Again, if you were diagnosed with gadolinium storage condition or gadolinium deposition disease, you should contact our law firm immediately. You may be entitled to compensation by filing a suit and we can help.