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Diabetes Drugs Linked to Severe Joint Pain: FDA Warning

The U.S. Food & Drug Administration (FDA) is warning that type 2 diabetes medications belonging to the DPP-4 class may cause severe and disabling pain in some users.


Free Diabetes Drug Lawsuit Evaluation: If you or a loved one has been injured by a DPP-4 diabetes medication, you should contact our law firm immediately. You may be entitled to compensation by filing a suit against the manufacturer and and our lawyers can help.

What’s the problem?

August 28, 2015 – The entire class of dipeptidyl peptidase-4 (DPP-4) inhibitor diabetes drugs have been linked to severe joint pain, according to an FDA Drug Safety Communication issued today.

“We have added a new Warning and Precaution about this risk to the labels of all medicines in this drug class, called dipeptidyl peptidase-4 (DPP-4) inhibitors,” FDA said.

Joint pain symptoms began from from one day to years after patients began taking a DPP-4 inhibitor, according to the FDA. In most cases, symptoms were relieved in less than a month after discontinuing use of the medication. Some patients suffered a recurrence of joint pain again when they restarted the same drug or another DPP-4 inhibitor.

Which Drugs are Affected?

DPP-4 inhibitors include:

Diabetes Drug Side Effects

In addition to the risk of severe joint pain, DPP-4 have also been linked to other severe side effects. Januvia, for example, can cause pancreatitis, a known risk factor for pancreatic cancer. Onglyza has been linked with an increased risk of heart failure.

FDA Recommendation

“Patients should not stop taking their DPP-4 inhibitor medicine, but should contact their health care professional right away if they experience severe and persistent joint pain,” FDA said. “Health care professionals should consider DPP-4 inhibitors as a possible cause of severe joint pain and discontinue the drug if appropriate.”

Do I Have a Diabetes Drug Lawsuit?

The Product Liability & Defective Drug Litigation Group at our law firm is an experienced team of trial lawyers that focus on the representation of plaintiffs in diabetes medication lawsuits. We are handling individual litigation nationwide and currently accepting new injury cases in all 50 states.

Again, if you or a loved one suffered an injury after taking a DPP-4 diabetes medication, you should contact our law firm immediately. You may be entitled to compensation by filing a suit and our lawyers can help.

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