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Avandia’s Effect on Other Medicines

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How Can Avandia Affect Other Medicines?

What’s the problem?

It is important to tell your healthcare professional what medicines you are already taking before you start treatment with Avandia. If Avandia is used in dual or triple therapy, in combination with a sulphonylurea such as gliclazide, the chance of your blood sugar dropping too low (hypoglycemia) may be increased. Your doctor may need to alter your dose of sulphonylurea to avoid this.

When Avandia is used as triple therapy, there may also be an increased risk of fluid retention and heart failure. It may be more suitable to use insulin instead of triple therapy, and your doctor should discuss this option with you.

There may be an increased risk of heart failure if Avandia is used with insulin. If you are taking Avandia in combination with insulin, it is important to let your doctor know if you are experiencing any shortness of breath, weight gain or swelling, particularly in the ankles.

There may be an increased risk of fluid retention if non-steroidal anti-inflammatory drugs (NSAIDs) such as diclofenac or ibuprofen are taken with Avandia.

The following medicines may decrease the blood level of Avandia and make it less effective at lowering blood sugar:

  • Rifampicin
  • Carbamazepine
  • Phenytoin
  • Phenobarbital
  • St John’s Wart

If you are taking any of these medications with Avandia, your blood sugar should be monitored to make sure the Avandia is still effective.

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