Do you have high blood pressure? If so, be advised Bristol-Myers Squibb is recalling Avalide because of an active ingredient consistency problem. May lower blood pressure to dangerous levels.
What’s the problem?
January 14, 2011 – This week, Bristol-Myers Squibb Co. announced that it will be recalling 60 million tablets (62 lots) of the blood pressure medication Avalide in the United States and Puerto Rico. The move to recall was reportedly made because of a potential variability in levels of the less-soluble form of the active ingredient irbesartan, which could result in slower dissolution. Avalide contains 300 mg of irbesartan and 25 mg of hydrochlorothiazide. Bristol-Myers reported sales of $307 million for Avalide and Avapro in the first half of 2010.
Chicago cardiologist Dr. Micah Eimer said he has not heard reports of Avalide adverse events, but noted that it is sometimes difficult to determine the cause of a problem:
“Some patients are on two, three, four or more medications, so what’s the pharmacological effect on each drug? It’s not easy to say. If the effect (of the drug) isn’t predictable, if (the drug strength) is too high or too low, it can affect kidney function, potassium levels, sodium, all sort of things,” he said. “There could be a wide range of effects if the drug isn’t predictable.”