Gadolinium-containing Ablavar™ contrast agents have recently been associated with the debilitating condition known as Nephrogenic Systemic Fibrosis (NSF)
What is Ablavar?
Ablavar is a contrast agent used for MRA evaluation of aortoiliac occlusive disease in patients with known or suspected peripheral vascular disease.
It is a blood-pool contrast agent that reversibly binds to albumin. Ablavar is designed to make the MRA examination more convenient because it is less dependent on bolus dynamics.
Nephrogenic Systemic Fibrosis (NSF) & Ablavar Contrast Dyes
In 2006, researchers discovered a direct association between NSF and the use of Gadolinium MRI contrast dyes such as Ablavar. Since that initial discovery, several other studies have reinforced the link between NSF and Gadolinium MRI contrast dyes. In 2006, the Food & Drug Administration (FDA) first warned doctors of this Gadolinium side effect. Then in 2007, the FDA ordered the manufactures of Gadolinium contrast dyes to add a black box warning – the strictest type of FDA warning — to their product labels advising of the risk of NSF to people with kidney problems.