Causes & Risk Factors of Chronic Myelogenous Leukemia

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Annually, nearly 5,000 individuals in the United States are diagnosed with chronic myelogenous leukemia and there are more than 20,000 individuals living with the condition in the Unites States today. Chronic myelogenous leukemia is one of the four main types of leukemia and is considered a progressive condition, meaning it gets worse as time goes on. Chronic myelogenous leukemia is caused when a specific chromosome in the body, called the Philadelphia chromosome, becomes corrupted. This corrupted chromosome sets off a chain reaction where the bone marrow of the body begins to produce corrupted stem cells that mature into abnormal blood cells. These abnormal blood cells are unable to perform the functions that they were intended for, multiply rapidly, and do not die when they should. This results in a build up of abnormal cells in the blood, which crowds out the normal, healthy blood cells that are needed by the body.

The factor that causes the corruption of the Philadelphia chromosome is still largely unknown, although researchers have identified some risk factors that may contribute to the development of the condition. Exposure to radiation or radiation therapy has been linked to the development of chronic myelogenous leukemia. Some survivors of the atomic bomb attacks at Hiroshima and Nagasaki, Japan have developed cases of chronic myelogenous leukemia, possibly as a result of long term exposure to high levels of radiation in the environment. Previous treatment for other types of cancer has also been associated with the development of chronic myelogenous leukemia. Most first line cancer treatments involve the use of chemotherapy or radiation therapy, which carries the risk of DNA corruption and can lead to the development of chronic myelogenous leukemia.

Long term exposure to high levels of certain chemicals, such as benzene, has also been associated with the development of chronic myelogenous leukemia. Benzene is a known carcinogen that is used in massive amounts in a large number of industries. Some of the industries that use large amounts of benzene in production or as an industrial solvent include the agriculture industry, the manufacturing industry, and the petroleum industry. Individuals that have been employed in these industries for a long period of time have an increased risk of developing many different types of cancer, including chronic myelogenous leukemia.

Not all individuals that have been exposed to these risk factors develop chronic myelogenous leukemia and some individuals develop chronic myelogenous leukemia without ever being exposed to these risk factors. Researchers are still working to understand why some individuals develop chronic myelogenous leukemia while others do not. It is known that chronic myelogenous leukemia is not a genetic condition and individuals cannot obtain chronic myelogenous leukemia through contact with others. Chronic myelogenous leukemia is present in all age groups, but occurs most often in individuals that are middle aged or older. Men seem to develop the condition more often than women, but only slightly more often. Chronic myelogenous leukemia represents one-fifth of all the diagnosed cases of adult leukemia in western civilization and the number of diagnosed cases increases slightly every year.

Chronic Myelogenous Leukemia (CML)

• Chronic Myelogenous Leukemia - CML (Overview)
• Signs & Symptoms
• Causes & Risk Factors
• Treatments

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There are many law firms in the United States that advertise their legal services for Benzene lawsuits, however most of these law firms do not actually litigate them. You can contact our law firm with confidence in knowing that we have earned the nationwide respect and recognition from our peers for the successful representation of Benzene exposure clients and their families.

If you or a loved one have been exposed to Benzene and developed a form of leukemia or other blood related disease, you should contact us immediately. You may be entitled to compensation and we can help.

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